Association of rs505080 Single Nucleotide Polymorphism in Lamin-A Gene with Familial Dilated Cardiomyopathy in Iranian Population; A Case-control Study

Background: Dilated cardiomyopathy (DCM) is among the most prevalent causes of heart failure and sudden cardiac death worldwide. Nuclear lamin protein coding genes are believed to have a definitive role in DCM phenotype. The rs505058 thymine (T) cytosine (C) polymorphism lamin-A gene one common mutations reported familial previous studies. Objectives: We aimed demonstrate possible this SNP A C (LMNA) incidence south Iran population. Methods: This case-control study included 65 patients with 70 healthy participants Iran. DNA was extracted from nucleated blood cells, polymerase chain reaction (PCR) performed. First, sequence LMNA investigated. Then frequency alleles (mutated allele) T (normal) (rs505058) compared between case controls. Results: No notable differences were seen gender age genotype frequencies T/C 6% (CC), 31% (CT), 63% (TT) amongst cases, 1% 13% (CT) 86% For allele level comparison, has been shown statistically significant association an enhancement risk dilated (OR = 2.92; 95% CI 1.05 8.15, P-value 0.034) Conclusions: results indicated that associated Iranian